Assay Detail
Binding
CHEMBL1022202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat microsomal DGAT1 by liquid scintillography
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL6129) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.89 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473384 | — | — | 1 | 8.05 |
| CHEMBL473967 | — | — | 1 | 7.72 |
| CHEMBL515415 | — | — | 1 | - |
| CHEMBL513992 | — | — | 1 | - |
| CHEMBL473385 | — | — | 1 | - |
| CHEMBL473386 | — | — | 1 | - |
| CHEMBL473982 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473384 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL473967 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL515415 | — | IC50 | - | — | - | |
| CHEMBL513992 | — | IC50 | - | — | - | |
| CHEMBL473385 | — | IC50 | - | — | - | |
| CHEMBL473386 | — | IC50 | - | — | - | |
| CHEMBL473982 | — | IC50 | - | — | - |