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Assay Detail

CHEMBL1022240

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
Williamson DS, Borgognoni J, Clay A, Daniels Z, Dokurno P, Drysdale MJ, Foloppe N, Francis GL, Graham CJ, Howes R, Macias AT, Murray JB, Parsons R, Shaw T, Surgenor AE, Terry L, Wang Y, Wood M, Massey AJ.
J Med Chem (2009) 52 : 1510 -1513
PubMed 19256508 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.64 6.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL470334 1 6.30
CHEMBL14249 ADENOSINE TRIPHOSPHATE 2.0 1 6.30
CHEMBL14830 ADENOSINE DIPHOSPHATE 0.5 1 6.30
CHEMBL447746 1 6.22
CHEMBL462871 1 6.05
CHEMBL472991 1 5.89
CHEMBL516992 1 5.77
CHEMBL538168 1 5.62
CHEMBL515570 1 5.54
CHEMBL473972 1 5.50
CHEMBL514313 1 5.31
CHEMBL516357 1 5.04
CHEMBL516197 1 5.03
CHEMBL473365 1 5.00
CHEMBL451058 1 4.77
CHEMBL477 ADENOSINE 4.0 1 -
CHEMBL502847 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL470334 IC50 = 500.0 nM 6.30
CHEMBL14249 ADENOSINE TRIPHOSPHATE IC50 = 500.0 nM 6.30
CHEMBL14830 ADENOSINE DIPHOSPHATE IC50 = 500.0 nM 6.30
CHEMBL447746 IC50 = 600.0 nM 6.22
CHEMBL462871 IC50 = 900.0 nM 6.05
CHEMBL472991 IC50 = 1300.0 nM 5.89
CHEMBL516992 IC50 = 1700.0 nM 5.77
CHEMBL538168 IC50 = 2400.0 nM 5.62
CHEMBL515570 IC50 = 2900.0 nM 5.54
CHEMBL473972 IC50 = 3200.0 nM 5.50
CHEMBL514313 IC50 = 4900.0 nM 5.31
CHEMBL516357 IC50 = 9100.0 nM 5.04
CHEMBL516197 IC50 = 9400.0 nM 5.03
CHEMBL473365 IC50 = 10000.0 nM 5.00
CHEMBL451058 IC50 = 17000.0 nM 4.77
CHEMBL477 ADENOSINE IC50 = 560000.0 nM -
CHEMBL502847 IC50 < 400.0 nM -