Assay Detail
Binding
CHEMBL1022370
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Inhibition of Src kinase
7
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based virtual screening of Src kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.01 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 2 | 9.22 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 8.92 |
| CHEMBL217092 | SARACATINIB | 3.0 | 2 | 8.52 |
| CHEMBL523122 | — | — | 1 | 7.05 |
| CHEMBL485304 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL523122 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL485304 | — | IC50 | = | 300.0 | nM | 6.52 |