Assay Detail
Binding
CHEMBL1022425
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 by liquid scintillation counting
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.00 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473826 | — | — | 1 | 5.82 |
| CHEMBL474863 | — | — | 1 | 5.36 |
| CHEMBL515109 | — | — | 1 | 5.32 |
| CHEMBL514511 | — | — | 1 | 5.21 |
| CHEMBL493315 | — | — | 1 | 5.17 |
| CHEMBL475796 | — | — | 1 | 5.11 |
| CHEMBL515258 | — | — | 1 | 5.07 |
| CHEMBL523684 | — | — | 1 | 5.07 |
| CHEMBL492956 | — | — | 1 | 5.06 |
| CHEMBL474046 | — | — | 1 | 5.05 |
| CHEMBL514351 | — | — | 1 | 5.04 |
| CHEMBL475820 | — | — | 1 | 5.01 |
| CHEMBL473825 | — | — | 1 | 4.96 |
| CHEMBL1080580 | — | — | 1 | 4.96 |
| CHEMBL474208 | — | — | 1 | 4.92 |
| CHEMBL521652 | — | — | 1 | 4.85 |
| CHEMBL474015 | — | — | 1 | 4.62 |
| CHEMBL941 | IMATINIB | 4.0 | 1 | 4.59 |
| CHEMBL475051 | — | — | 1 | 4.37 |
| CHEMBL515432 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473826 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL474863 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL515109 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL514511 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL493315 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL475796 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL515258 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL523684 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL492956 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL474046 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL514351 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL475820 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL473825 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1080580 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL474208 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL521652 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL474015 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL941 | IMATINIB | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL475051 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL515432 | — | IC50 | = | 46000.0 | nM | 4.34 |