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Assay Detail

CHEMBL1022586

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of MAOA in rat liver homogenates preincubated for 60 mins
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Tissue Liver
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL3358)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Jayaprakash V, Sinha BN, Ucar G, Ercan A.
Bioorg Med Chem Lett (2008) 18 : 6362 -6368
PubMed 18980841 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 36 4.57 5.69

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL8706 CLORGILINE 2.0 1 5.69
CHEMBL517888 1 5.55
CHEMBL86304 MOCLOBEMIDE 4.0 1 5.41
CHEMBL462549 1 5.25
CHEMBL452092 1 4.70
CHEMBL511095 1 4.63
CHEMBL462550 1 4.49
CHEMBL518827 1 4.48
CHEMBL512676 1 4.40
CHEMBL462229 1 4.31
CHEMBL470312 1 4.31
CHEMBL471348 1 4.30
CHEMBL472568 1 4.27
CHEMBL508880 1 4.24
CHEMBL514763 1 4.23
CHEMBL513578 1 4.18
CHEMBL509681 1 4.17
CHEMBL472569 1 4.16
CHEMBL510122 1 4.13
CHEMBL470493 1 -
CHEMBL972 SELEGILINE 4.0 1 -
CHEMBL499684 1 -
CHEMBL673 PARGYLINE 4.0 1 -
CHEMBL521219 1 -
CHEMBL487249 1 -
CHEMBL487248 1 -
CHEMBL471356 1 -
CHEMBL470494 1 -
CHEMBL470308 1 -
CHEMBL511459 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL8706 CLORGILINE IC50 = 2050.0 nM 5.69
CHEMBL517888 IC50 = 2840.0 nM 5.55
CHEMBL86304 MOCLOBEMIDE IC50 = 3900.0 nM 5.41
CHEMBL462549 IC50 = 5560.0 nM 5.25
CHEMBL452092 IC50 = 20050.0 nM 4.70
CHEMBL511095 IC50 = 23180.0 nM 4.63
CHEMBL462550 IC50 = 32100.0 nM 4.49
CHEMBL518827 IC50 = 33410.0 nM 4.48
CHEMBL512676 IC50 = 40070.0 nM 4.40
CHEMBL470312 IC50 = 48900.0 nM 4.31
CHEMBL462229 IC50 = 49160.0 nM 4.31
CHEMBL471348 IC50 = 50640.0 nM 4.30
CHEMBL472568 IC50 = 53360.0 nM 4.27
CHEMBL508880 IC50 = 58100.0 nM 4.24
CHEMBL514763 IC50 = 58600.0 nM 4.23
CHEMBL513578 IC50 = 65600.0 nM 4.18
CHEMBL509681 IC50 = 67220.0 nM 4.17
CHEMBL472569 IC50 = 69550.0 nM 4.16
CHEMBL510122 IC50 = 74200.0 nM 4.13
CHEMBL470494 IC50 = 147800.0 nM -
CHEMBL512675 IC50 = 400200.0 nM -
CHEMBL470307 IC50 = 400560.0 nM -
CHEMBL472555 IC50 = 470500.0 nM -
CHEMBL513995 IC50 = 475560.0 nM -
CHEMBL461146 IC50 = 450800.0 nM -
CHEMBL472570 IC50 = 150600.0 nM -
CHEMBL511459 IC50 = 144480.0 nM -
CHEMBL470308 IC50 = 475500.0 nM -
CHEMBL470493 IC50 = 170460.0 nM -
CHEMBL471356 IC50 = 180230.0 nM -
CHEMBL487248 IC50 = 188510.0 nM -
CHEMBL487249 IC50 = 170260.0 nM -
CHEMBL521219 IC50 = 200560.0 nM -
CHEMBL673 PARGYLINE IC50 = 390200.0 nM -
CHEMBL499684 IC50 = 466200.0 nM -
CHEMBL972 SELEGILINE IC50 = 499010.0 nM -