Assay Detail
Functional
CHEMBL1022592
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Antiproliferative activity against human LoVo cells assessed as inhibition of BrdU incorporation after 48 hrs
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LoVo |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.30 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL455651 | — | — | 1 | 7.16 |
| CHEMBL455429 | — | — | 1 | 7.00 |
| CHEMBL453862 | — | — | 1 | 6.89 |
| CHEMBL455428 | — | — | 1 | 6.85 |
| CHEMBL454648 | — | — | 1 | 6.77 |
| CHEMBL453655 | — | — | 1 | 6.72 |
| CHEMBL488257 | — | — | 1 | 6.72 |
| CHEMBL509881 | — | — | 1 | 6.57 |
| CHEMBL510436 | — | — | 1 | 6.44 |
| CHEMBL508129 | — | — | 1 | 6.33 |
| CHEMBL488085 | — | — | 1 | 6.32 |
| CHEMBL487066 | — | — | 1 | 6.22 |
| CHEMBL507142 | — | — | 1 | 6.18 |
| CHEMBL488084 | — | — | 1 | 6.16 |
| CHEMBL488436 | AZD-5438 | 1.0 | 1 | 6.10 |
| CHEMBL488256 | — | — | 1 | 5.68 |
| CHEMBL508739 | — | — | 1 | 5.64 |
| CHEMBL453651 | — | — | 1 | 5.54 |
| CHEMBL519422 | — | — | 1 | 5.51 |
| CHEMBL487067 | — | — | 1 | 5.24 |
| CHEMBL455427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL455651 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL455429 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL453862 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL455428 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL454648 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL453655 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL488257 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL509881 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL510436 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL508129 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL488085 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL487066 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL507142 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL488084 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL488436 | AZD-5438 | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL488256 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL508739 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL453651 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL519422 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL487067 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL455427 | — | IC50 | - | — | - |