Assay Detail
Binding
CHEMBL1022736
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Inhibition of IGF1R in mouse SAL cells assessed as thymidine incorporation
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | SAL |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Insulin-like growth factor 1 receptor (CHEMBL5381) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.00 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL521271 | — | — | 1 | 7.41 |
| CHEMBL482089 | — | — | 1 | 7.26 |
| CHEMBL480966 | — | — | 1 | 7.18 |
| CHEMBL505919 | — | — | 1 | 7.11 |
| CHEMBL520419 | — | — | 1 | 7.10 |
| CHEMBL454467 | — | — | 1 | 7.10 |
| CHEMBL502092 | — | — | 1 | 7.08 |
| CHEMBL474469 | — | — | 1 | 7.07 |
| CHEMBL451331 | — | — | 1 | 7.06 |
| CHEMBL519300 | — | — | 1 | 7.04 |
| CHEMBL482088 | — | — | 1 | 7.00 |
| CHEMBL459118 | — | — | 1 | 7.00 |
| CHEMBL506169 | — | — | 1 | 6.98 |
| CHEMBL482126 | — | — | 1 | 6.97 |
| CHEMBL480965 | — | — | 1 | 6.97 |
| CHEMBL482102 | — | — | 1 | 6.97 |
| CHEMBL401930 | — | — | 1 | 6.96 |
| CHEMBL450610 | — | — | 1 | 6.94 |
| CHEMBL482101 | — | — | 1 | 6.92 |
| CHEMBL505652 | — | — | 1 | 6.89 |
| CHEMBL510298 | — | — | 1 | 6.86 |
| CHEMBL499584 | — | — | 1 | 6.84 |
| CHEMBL454515 | — | — | 1 | 6.82 |
| CHEMBL519132 | — | — | 1 | 6.81 |
| CHEMBL502778 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL521271 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL482089 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL480966 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL505919 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL520419 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL454467 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL502092 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL474469 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL451331 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL519300 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL482088 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL459118 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL506169 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL482126 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL480965 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL482102 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL401930 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL450610 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL482101 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL505652 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL510298 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL499584 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL454515 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL519132 | — | IC50 | = | 155.0 | nM | 6.81 |
| CHEMBL502778 | — | IC50 | = | 193.0 | nM | 6.71 |