Assay Detail
Binding
CHEMBL1022993
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Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.78 | 9.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL514774 | — | — | 1 | 9.32 |
| CHEMBL386492 | CLOCINNAMOX | — | 1 | 8.57 |
| CHEMBL386272 | — | — | 1 | 8.32 |
| CHEMBL19019 | NALTREXONE | 4.0 | 1 | 7.96 |
| CHEMBL512526 | — | — | 1 | 6.96 |
| CHEMBL474755 | — | — | 1 | 6.75 |
| CHEMBL471543 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL514774 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL386492 | CLOCINNAMOX | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL386272 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL19019 | NALTREXONE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL512526 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL474755 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL471543 | — | Ki | = | 270.0 | nM | 6.57 |