Assay Detail
Functional
CHEMBL1023002
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Agonist activity at human delta opioid receptor expressed in CHO cells assessed as stimulation of [35S]GTPgammaS binding
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
14 beta-O-cinnamoylnaltrexone and related dihydrocodeinones are mu opioid receptor partial agonists with predominant antagonist activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.44 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.50 |
| CHEMBL474755 | — | — | 1 | 6.37 |
| CHEMBL386272 | — | — | 1 | - |
| CHEMBL471543 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | EC50 | = | 316.0 | nM | 6.50 |
| CHEMBL474755 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL386272 | — | EC50 | - | — | - | |
| CHEMBL471543 | — | EC50 | - | — | - |