Assay Detail
Binding
CHEMBL1023029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PDE4D3
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3',5'-cyclic-AMP phosphodiesterase 4D (CHEMBL288) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual inhibitors of phosphodiesterase-4 and serotonin reuptake.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.34 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451500 | — | — | 1 | 8.92 |
| CHEMBL505431 | — | — | 1 | 8.70 |
| CHEMBL463431 | — | — | 1 | 8.64 |
| CHEMBL313041 | — | — | 1 | 8.20 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451500 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL505431 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL463431 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL313041 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL63 | ROLIPRAM | Ki | = | 58.9 | nM | 7.23 |