Assay Detail
Binding
CHEMBL1023076
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Inhibition of Electron transport protein complex 1 in bovine heart submitochondrial particles assessed as NADH oxidase activity by spectrophotometric analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and characterization of Deltalac-acetogenins that potently inhibit mitochondrial complex I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.64 | 7.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464549 | dleta-lac-Acetogenin | — | 1 | 7.91 |
| CHEMBL498986 | — | — | 1 | 7.71 |
| CHEMBL457770 | — | — | 1 | 7.52 |
| CHEMBL503220 | — | — | 1 | 7.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464549 | dleta-lac-Acetogenin | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL498986 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL457770 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL503220 | — | IC50 | = | 38.8 | nM | 7.41 |