Assay Detail
Binding
CHEMBL1023104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.84 | 5.96 |
| Ki | 1 | 4.31 | 4.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL237336 | — | — | 1 | 5.96 |
| CHEMBL237119 | — | — | 1 | 5.34 |
| CHEMBL257023 | — | — | 1 | 4.72 |
| CHEMBL22310 | — | — | 1 | 4.31 |
| CHEMBL445949 | — | — | 1 | 4.12 |
| CHEMBL459357 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL237336 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL237119 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL257023 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL22310 | — | Ki | = | 49000.0 | nM | 4.31 |
| CHEMBL445949 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL459357 | — | IC50 | = | 86000.0 | nM | 4.07 |