Assay Detail
Binding
CHEMBL1023322
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Inhibition of 5-lipoxygenase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.65 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL470129 | — | — | 1 | 6.70 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.30 |
| CHEMBL450070 | ATRACTYLOCHROMENE | — | 1 | 6.22 |
| CHEMBL486189 | ATRACTYLON | — | 1 | 4.60 |
| CHEMBL52229 | OSTHOLE | — | 1 | 4.44 |
| CHEMBL486961 | ATRACTYLENOLIDE III | — | 1 | - |
| CHEMBL485805 | ATRACTYLENOLIDE II | — | 1 | - |
| CHEMBL449520 | ATRACTYLENOLIDE I | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL470129 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL450070 | ATRACTYLOCHROMENE | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL486189 | ATRACTYLON | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL52229 | OSTHOLE | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL486961 | ATRACTYLENOLIDE III | IC50 | > | 200000.0 | nM | - |
| CHEMBL485805 | ATRACTYLENOLIDE II | IC50 | > | 200000.0 | nM | - |
| CHEMBL449520 | ATRACTYLENOLIDE I | IC50 | > | 200000.0 | nM | - |