Assay Detail
Binding
CHEMBL1023845
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Inhibition of VEGFR2 at IC90 concentration by ATP based competition assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3,4-Disubstituted isothiazoles: novel potent inhibitors of VEGF receptors 1 and 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.99 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473288 | — | — | 1 | 7.16 |
| CHEMBL475510 | — | — | 1 | 6.92 |
| CHEMBL515880 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473288 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL475510 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL515880 | — | Ki | = | 130.0 | nM | 6.89 |