Assay Detail
Functional
CHEMBL1023917
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Antagonist activity at calcium channel in guinea pig ileum assessed as inhibition of KCl-induced contraction of ileal longitudinal smooth muscle pretreated 15 mins before KCl challenge
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of some new 1,4-dihydropyridines containing different ester substitute and diethyl carbamoyl group as anti-tubercular agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.40 | 8.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 8.97 |
| CHEMBL514592 | — | — | 1 | 5.62 |
| CHEMBL458350 | — | — | 1 | 5.57 |
| CHEMBL515047 | — | — | 1 | 5.46 |
| CHEMBL458344 | — | — | 1 | 5.38 |
| CHEMBL458159 | — | — | 1 | 5.07 |
| CHEMBL459389 | — | — | 1 | 4.92 |
| CHEMBL459596 | — | — | 1 | 4.73 |
| CHEMBL457033 | — | — | 1 | 4.62 |
| CHEMBL516937 | — | — | 1 | 4.53 |
| CHEMBL459593 | — | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL193 | NIFEDIPINE | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL514592 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL458350 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL515047 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL458344 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL458159 | — | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL459389 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL459596 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL457033 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL516937 | — | IC50 | = | 29700.0 | nM | 4.53 |
| CHEMBL459593 | — | IC50 | = | 32200.0 | nM | 4.49 |