Assay Detail
Functional
CHEMBL1024216
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Inhibition of H2O2-induced cell death of rat thymocyte assessed as cell viability
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Thymocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of (+/-)-cassumunins A and B, new curcuminoid antioxidants having protective activity of the living cell against oxidative damage.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.47 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473041 | CASSUMUNIN A | — | 1 | 6.77 |
| CHEMBL450047 | CASSUMUNIN B | — | 1 | 6.66 |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473041 | CASSUMUNIN A | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL450047 | CASSUMUNIN B | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL140 | CURCUMIN | IC50 | = | 1020.0 | nM | 5.99 |