Assay Detail
Binding
CHEMBL1024276
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Inhibition of HIV1 reverse transcriptase after 1 hr by ELISA
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, microwave-assisted synthesis and HIV-RT inhibitory activity of 2-(2,6-dihalophenyl)-3-(4,6-dimethyl-5-(un)substituted-pyrimidin-2-yl)thiazolidin-4-ones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.69 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487954 | — | — | 1 | 6.64 |
| CHEMBL522748 | — | — | 1 | 6.58 |
| CHEMBL390110 | — | — | 1 | 6.42 |
| CHEMBL496888 | — | — | 1 | 6.11 |
| CHEMBL390956 | — | — | 1 | 6.08 |
| CHEMBL518929 | — | — | 1 | 6.07 |
| CHEMBL463594 | — | — | 1 | 5.99 |
| CHEMBL518536 | — | — | 1 | 5.91 |
| CHEMBL520199 | — | — | 1 | 5.82 |
| CHEMBL487140 | — | — | 1 | 5.70 |
| CHEMBL486939 | — | — | 1 | 5.54 |
| CHEMBL497056 | — | — | 1 | 5.37 |
| CHEMBL517008 | — | — | 1 | 5.01 |
| CHEMBL486937 | — | — | 1 | 4.80 |
| CHEMBL486938 | — | — | 1 | 4.79 |
| CHEMBL463593 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487954 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL522748 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL390110 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL496888 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL390956 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL518929 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL463594 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL518536 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL520199 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL487140 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL486939 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL497056 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL517008 | — | IC50 | = | 9820.0 | nM | 5.01 |
| CHEMBL486937 | — | IC50 | = | 15960.0 | nM | 4.80 |
| CHEMBL486938 | — | IC50 | = | 16150.0 | nM | 4.79 |
| CHEMBL463593 | — | IC50 | = | 74390.0 | nM | 4.13 |