Assay Detail
Functional
CHEMBL1024356
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Antiviral activity against Human cytomegalovirus Towne in HFF by plaque reduction assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human betaherpesvirus 5 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.58 | 6.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | 2.0 | 1 | 6.34 |
| CHEMBL554910 | — | — | 1 | 5.66 |
| CHEMBL550615 | — | — | 1 | 5.62 |
| CHEMBL372938 | — | — | 1 | 4.70 |
| CHEMBL572812 | — | — | 1 | - |
| CHEMBL559499 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265948 | FILOCICLOVIR | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL554910 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL550615 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL372938 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL572812 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL559499 | — | EC50 | > | 100000.0 | nM | - |