Assay Detail
Binding
CHEMBL1024395
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Inhibition of c-SRC SH2 domain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Proto-oncogene tyrosine-protein kinase Src (CHEMBL267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Natural product inhibitors of protein-protein interactions mediated by Src-family SH2 domains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.30 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | 4.58 |
| CHEMBL457077 | SALVIANOLIC ACID A | 1.0 | 1 | 4.44 |
| CHEMBL558557 | CAFTARIC ACID | — | 1 | 4.13 |
| CHEMBL541265 | SALVIANOLIC ACID B | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324842 | ROSMARINIC ACID | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL457077 | SALVIANOLIC ACID A | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL558557 | CAFTARIC ACID | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL541265 | SALVIANOLIC ACID B | IC50 | = | 90000.0 | nM | 4.05 |