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Assay Detail

CHEMBL1024480

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Binding
Inhibition of Bacillus anthracis lethal factor assessed as cleavage of MAPKK by fluorescence peptide cleavage assay
ChEMBL ↗
131
Total Activities
123
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bacillus anthracis
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Lethal factor (CHEMBL4372) ↗
Type SINGLE PROTEIN
Organism Bacillus anthracis

Publication

Structure-activity relationship studies of a novel series of anthrax lethal factor inhibitors.
Johnson SL, Chen LH, Barile E, Emdadi A, Sabet M, Yuan H, Wei J, Guiney D, Pellecchia M.
Bioorg Med Chem (2009) 17 : 3352 -3368
PubMed 19359184 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 123 4.84 5.52
Ki 8 5.66 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL466960 — — 2 6.42
CHEMBL560968 — — 2 6.25
CHEMBL563737 — — 2 6.00
CHEMBL551180 — — 2 5.77
CHEMBL551580 — — 1 5.52
CHEMBL562309 — — 1 5.41
CHEMBL561169 — — 2 5.38
CHEMBL562564 — — 1 5.35
CHEMBL569602 — — 2 5.30
CHEMBL563193 — — 2 5.18
CHEMBL558685 — — 1 5.18
CHEMBL564281 — — 1 5.14
CHEMBL561366 — — 2 5.11
CHEMBL560969 — — 1 5.10
CHEMBL551099 — — 1 5.10
CHEMBL556889 — — 1 5.10
CHEMBL563584 — — 1 5.10
CHEMBL564671 — — 1 5.05
CHEMBL559082 — — 1 5.05
CHEMBL561046 — — 1 5.05
CHEMBL552103 — — 1 5.05
CHEMBL558099 — — 1 5.03
CHEMBL563882 — — 1 5.03
CHEMBL560223 — — 1 5.02
CHEMBL564771 — — 1 5.00
CHEMBL556471 — — 1 5.00
CHEMBL559911 — — 1 5.00
CHEMBL564053 — — 1 5.00
CHEMBL559516 — — 1 4.96
CHEMBL560966 — — 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL466960 — Ki = 380.0 nM 6.42
CHEMBL560968 — Ki = 560.0 nM 6.25
CHEMBL563737 — Ki = 1000.0 nM 6.00
CHEMBL551180 — Ki = 1700.0 nM 5.77
CHEMBL551180 — IC50 = 3000.0 nM 5.52
CHEMBL551580 — IC50 = 3000.0 nM 5.52
CHEMBL560968 — IC50 = 3400.0 nM 5.47
CHEMBL563737 — IC50 = 3800.0 nM 5.42
CHEMBL562309 — IC50 = 3900.0 nM 5.41
CHEMBL561169 — IC50 = 4200.0 nM 5.38
CHEMBL562564 — IC50 = 4500.0 nM 5.35
CHEMBL466960 — IC50 = 4800.0 nM 5.32
CHEMBL569602 — Ki = 5000.0 nM 5.30
CHEMBL561169 — Ki = 5900.0 nM 5.23
CHEMBL558685 — IC50 = 6600.0 nM 5.18
CHEMBL563193 — Ki = 6600.0 nM 5.18
CHEMBL564281 — IC50 = 7200.0 nM 5.14
CHEMBL561366 — Ki = 7800.0 nM 5.11
CHEMBL563584 — IC50 = 8000.0 nM 5.10
CHEMBL551099 — IC50 = 8000.0 nM 5.10
CHEMBL556889 — IC50 = 8000.0 nM 5.10
CHEMBL560969 — IC50 = 8000.0 nM 5.10
CHEMBL561046 — IC50 = 9000.0 nM 5.05
CHEMBL559082 — IC50 = 9000.0 nM 5.05
CHEMBL564671 — IC50 = 8900.0 nM 5.05
CHEMBL552103 — IC50 = 9000.0 nM 5.05
CHEMBL558099 — IC50 = 9300.0 nM 5.03
CHEMBL563882 — IC50 = 9400.0 nM 5.03
CHEMBL560223 — IC50 = 9600.0 nM 5.02
CHEMBL556471 — IC50 = 10000.0 nM 5.00
CHEMBL564053 — IC50 = 10000.0 nM 5.00
CHEMBL564771 — IC50 = 10000.0 nM 5.00
CHEMBL559911 — IC50 = 10000.0 nM 5.00
CHEMBL560966 — IC50 = 11000.0 nM 4.96
CHEMBL556885 — IC50 = 11000.0 nM 4.96
CHEMBL551444 — IC50 = 11000.0 nM 4.96
CHEMBL565138 — IC50 = 11000.0 nM 4.96
CHEMBL564208 — IC50 = 11000.0 nM 4.96
CHEMBL552451 — IC50 = 11000.0 nM 4.96
CHEMBL560426 — IC50 = 11000.0 nM 4.96
CHEMBL559516 — IC50 = 11000.0 nM 4.96
CHEMBL562428 — IC50 = 12000.0 nM 4.92
CHEMBL562697 — IC50 = 12000.0 nM 4.92
CHEMBL564869 — IC50 = 12000.0 nM 4.92
CHEMBL569602 — IC50 = 12000.0 nM 4.92
CHEMBL561365 — IC50 = 12000.0 nM 4.92
CHEMBL564956 — IC50 = 12000.0 nM 4.92
CHEMBL550900 — IC50 = 13000.0 nM 4.89
CHEMBL561506 — IC50 = 13000.0 nM 4.89
CHEMBL559772 — IC50 = 13000.0 nM 4.89