Assay Detail
Binding
CHEMBL1024557
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Inhibition of tetrodotoxin-sensitive sodium channel
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.84 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL541226 | — | — | 1 | 6.08 |
| CHEMBL559456 | — | — | 1 | 5.60 |
| CHEMBL150932 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL541226 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL559456 | — | IC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL150932 | — | IC50 | - | — | - |