Assay Detail
Functional
CHEMBL1024586
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human KB cells by methylene blue assay
46
Total Activities
46
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 46 | 6.76 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL560431 | — | — | 1 | 8.92 |
| CHEMBL562826 | — | — | 1 | 8.41 |
| CHEMBL550214 | — | — | 1 | 8.26 |
| CHEMBL565113 | — | — | 1 | 8.18 |
| CHEMBL564967 | — | — | 1 | 7.96 |
| CHEMBL559629 | — | — | 1 | 7.84 |
| CHEMBL558278 | — | — | 1 | 7.47 |
| CHEMBL561697 | — | — | 1 | 7.42 |
| CHEMBL562234 | — | — | 1 | 7.42 |
| CHEMBL562921 | — | — | 1 | 7.30 |
| CHEMBL560631 | — | — | 1 | 7.26 |
| CHEMBL549738 | — | — | 1 | 7.24 |
| CHEMBL557073 | — | — | 1 | 7.19 |
| CHEMBL550423 | — | — | 1 | 7.16 |
| CHEMBL557074 | — | — | 1 | 7.14 |
| CHEMBL561032 | — | — | 1 | 7.12 |
| CHEMBL560097 | — | — | 1 | 7.04 |
| CHEMBL564851 | — | — | 1 | 7.03 |
| CHEMBL561229 | — | — | 1 | 6.75 |
| CHEMBL564979 | — | — | 1 | 6.73 |
| CHEMBL563790 | — | — | 1 | 6.70 |
| CHEMBL561897 | — | — | 1 | 6.70 |
| CHEMBL552092 | — | — | 1 | 6.68 |
| CHEMBL560496 | — | — | 1 | 6.68 |
| CHEMBL562688 | — | — | 1 | 6.65 |
| CHEMBL549813 | — | — | 1 | 6.62 |
| CHEMBL560354 | — | — | 1 | 6.55 |
| CHEMBL558281 | — | — | 1 | 6.54 |
| CHEMBL560498 | — | — | 1 | 6.54 |
| CHEMBL559430 | — | — | 1 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL560431 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL562826 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL550214 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL565113 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL564967 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL559629 | — | IC50 | = | 14.3 | nM | 7.84 |
| CHEMBL558278 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL561697 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL562234 | — | IC50 | = | 37.8 | nM | 7.42 |
| CHEMBL562921 | — | IC50 | = | 49.75 | nM | 7.30 |
| CHEMBL560631 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL549738 | — | IC50 | = | 57.3 | nM | 7.24 |
| CHEMBL557073 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL550423 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL557074 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL561032 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL560097 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL564851 | — | IC50 | = | 93.0 | nM | 7.03 |
| CHEMBL561229 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL564979 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL563790 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL561897 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL560496 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL552092 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL562688 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL549813 | — | IC50 | = | 237.0 | nM | 6.62 |
| CHEMBL560354 | — | IC50 | = | 279.8 | nM | 6.55 |
| CHEMBL558281 | — | IC50 | = | 288.1 | nM | 6.54 |
| CHEMBL560498 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL559430 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL560231 | — | IC50 | = | 292.5 | nM | 6.53 |
| CHEMBL554942 | — | IC50 | = | 331.6 | nM | 6.48 |
| CHEMBL561431 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL550891 | — | IC50 | = | 346.0 | nM | 6.46 |
| CHEMBL560433 | — | IC50 | = | 406.1 | nM | 6.39 |
| CHEMBL549938 | — | IC50 | = | 455.0 | nM | 6.34 |
| CHEMBL560434 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL562494 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL552386 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL564602 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL541687 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL563464 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL551093 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL559505 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL561557 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL564174 | — | IC50 | = | 6000.0 | nM | 5.22 |