Assay Detail
Binding
CHEMBL1024687
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Inhibition of human DNA polymerase beta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Alpha,beta-methylene-2'-deoxynucleoside 5'-triphosphates as noncleavable substrates for DNA polymerases: isolation, characterization, and stability studies of novel 2'-deoxycyclonucleosides, 3,5'-cyclo-dG, and 2,5'-cyclo-dT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.89 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162299 | — | — | 1 | 6.22 |
| CHEMBL1162298 | — | — | 1 | 6.05 |
| CHEMBL1162300 | — | — | 1 | 6.00 |
| CHEMBL1162297 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162299 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL1162298 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL1162300 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL1162297 | — | Ki | = | 5000.0 | nM | 5.30 |