Assay Detail
Binding
CHEMBL1024699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]substance P from human NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 9.24 | 10.08 |
| IC50 | 4 | 9.50 | 10.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507340 | — | — | 2 | 10.90 |
| CHEMBL389652 | — | — | 2 | 10.08 |
| CHEMBL22870 | L-732138 | — | 2 | 9.14 |
| CHEMBL448998 | — | — | 2 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507340 | — | IC50 | = | 0.01259 | nM | 10.90 |
| CHEMBL389652 | — | Ki | = | 0.084 | nM | 10.08 |
| CHEMBL389652 | — | IC50 | = | 0.1259 | nM | 9.90 |
| CHEMBL22870 | L-732138 | Ki | = | 0.73 | nM | 9.14 |
| CHEMBL22870 | L-732138 | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL448998 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL448998 | — | IC50 | = | 3.981 | nM | 8.40 |
| CHEMBL507340 | — | Ki | = | 0.0065 | nM | - |