Assay Detail
Binding
CHEMBL1024700
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]substance P from rat NK1 receptor expressed in CHO cell membrane by liquid scintillation counting
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.68 | 9.54 |
| IC50 | 4 | 7.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL389652 | — | — | 2 | 9.54 |
| CHEMBL507340 | — | — | 2 | 8.14 |
| CHEMBL22870 | L-732138 | — | 2 | 6.89 |
| CHEMBL448998 | — | — | 2 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL389652 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL389652 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL507340 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL507340 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL22870 | L-732138 | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL22870 | L-732138 | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL448998 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL448998 | — | IC50 | = | 2511.89 | nM | 5.60 |