Assay Detail
Functional
CHEMBL1024702
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Agonist activity at human delta opioid receptor expressed in mouse HN9.10 cells by [35S]GTPgammaS binding assay
10
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The importance of micelle-bound states for the bioactivities of bifunctional peptide derivatives for delta/mu opioid receptor agonists and neurokinin 1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.60 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | — | 2 | 9.00 |
| CHEMBL31421 | — | — | 2 | 8.80 |
| CHEMBL448998 | — | — | 2 | 8.60 |
| CHEMBL389652 | — | — | 2 | 8.54 |
| CHEMBL507340 | — | — | 2 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL200199 | BIPHALIN | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL31421 | — | EC50 | = | 1.6 | nM | 8.80 |
| CHEMBL31421 | — | EC50 | = | 1.585 | nM | 8.80 |
| CHEMBL448998 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL448998 | — | EC50 | = | 2.6 | nM | 8.59 |
| CHEMBL389652 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL389652 | — | EC50 | = | 3.162 | nM | 8.50 |
| CHEMBL507340 | — | EC50 | = | 7.943 | nM | 8.10 |
| CHEMBL507340 | — | EC50 | = | 8.6 | nM | 8.07 |