Assay Detail
Functional
CHEMBL1025055
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Cytotoxicity against human TK10 cells after 48 hrs by SRB assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | TK-10 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.89 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 8.49 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 7.84 |
| CHEMBL1453 | DIGITOXIGENIN | — | 1 | 7.12 |
| CHEMBL109317 | GITOXIN | — | 1 | 6.88 |
| CHEMBL1153 | DIGOXIGENIN | — | 1 | 6.50 |
| CHEMBL464658 | GITOXIGENIN | — | 1 | 6.38 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 14.6 | nM | 7.84 |
| CHEMBL1453 | DIGITOXIGENIN | IC50 | = | 76.5 | nM | 7.12 |
| CHEMBL109317 | GITOXIN | IC50 | = | 131.2 | nM | 6.88 |
| CHEMBL1153 | DIGOXIGENIN | IC50 | = | 317.5 | nM | 6.50 |
| CHEMBL464658 | GITOXIGENIN | IC50 | = | 415.6 | nM | 6.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 9952.5 | nM | 5.00 |