Assay Detail
Functional
CHEMBL1025150
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Antitumor activity against human MALME-3M cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Malme-3M |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Recent advances in the development of polyamine analogues as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.07 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | — | 1 | 6.70 |
| CHEMBL77101 | DIETHYLHOMOSPERMINE | 1.0 | 1 | 6.00 |
| CHEMBL83896 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44083 | BIS(ETHYL)NORSPERMINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL77101 | DIETHYLHOMOSPERMINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL83896 | — | IC50 | = | 3000.0 | nM | 5.52 |