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Assay Detail

CHEMBL1025545

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of His6x-tagged yeast recombinant Esa1 (105-445) expressed in Escherichia coli BL21 (DE3) by liquid scintillation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Saccharomyces cerevisiae
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.
Wu J, Xie N, Wu Z, Zhang Y, Zheng YG.
Bioorg Med Chem (2009) 17 : 1381 -1386
PubMed 19114310 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 4.89 5.32

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL526343 1 5.32
CHEMBL504265 1 5.26
CHEMBL505121 1 5.16
CHEMBL509144 1 4.92
CHEMBL448227 1 4.86
CHEMBL505605 1 4.74
CHEMBL500256 1 4.69
CHEMBL1213327 COENZYME_A 3.0 1 4.16
CHEMBL455368 ANACARDIC ACID 1 -
CHEMBL140 CURCUMIN 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL526343 IC50 = 4780.0 nM 5.32
CHEMBL504265 IC50 = 5510.0 nM 5.26
CHEMBL505121 IC50 = 7000.0 nM 5.16
CHEMBL509144 IC50 = 12090.0 nM 4.92
CHEMBL448227 IC50 = 13940.0 nM 4.86
CHEMBL505605 IC50 = 18330.0 nM 4.74
CHEMBL500256 IC50 = 20300.0 nM 4.69
CHEMBL1213327 COENZYME_A IC50 = 68580.0 nM 4.16
CHEMBL455368 ANACARDIC ACID IC50 = 297230.0 nM -
CHEMBL140 CURCUMIN IC50 > 150000.0 nM -