Assay Detail
Binding
CHEMBL1025546
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Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.46 | 4.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL504265 | — | — | 1 | 4.76 |
| CHEMBL509144 | — | — | 1 | 4.68 |
| CHEMBL500256 | — | — | 1 | 4.59 |
| CHEMBL505121 | — | — | 1 | 4.53 |
| CHEMBL526343 | — | — | 1 | 4.10 |
| CHEMBL1213327 | COENZYME_A | 3.0 | 1 | 4.08 |
| CHEMBL505605 | — | — | 1 | - |
| CHEMBL448227 | — | — | 1 | - |
| CHEMBL455368 | ANACARDIC ACID | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL504265 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL509144 | — | IC50 | = | 20910.0 | nM | 4.68 |
| CHEMBL500256 | — | IC50 | = | 25870.0 | nM | 4.59 |
| CHEMBL505121 | — | IC50 | = | 29750.0 | nM | 4.53 |
| CHEMBL526343 | — | IC50 | = | 79620.0 | nM | 4.10 |
| CHEMBL1213327 | COENZYME_A | IC50 | = | 82270.0 | nM | 4.08 |
| CHEMBL505605 | — | IC50 | = | 143350.0 | nM | - |
| CHEMBL448227 | — | IC50 | = | 111700.0 | nM | - |
| CHEMBL455368 | ANACARDIC ACID | IC50 | = | 374590.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 200000.0 | nM | - |