Assay Detail
Binding
CHEMBL1025548
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Inhibition of recombinant p300
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Bisubstrate Inhibitors of the MYST HATs Esa1 and Tip60.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.18 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505121 | — | — | 1 | 6.01 |
| CHEMBL505605 | — | — | 1 | 5.54 |
| CHEMBL500256 | — | — | 1 | 5.36 |
| CHEMBL504265 | — | — | 1 | 5.18 |
| CHEMBL526343 | — | — | 1 | 5.12 |
| CHEMBL448227 | — | — | 1 | 5.09 |
| CHEMBL509144 | — | — | 1 | 4.76 |
| CHEMBL1213327 | COENZYME_A | 3.0 | 1 | 4.34 |
| CHEMBL455368 | ANACARDIC ACID | — | 1 | - |
| CHEMBL140 | CURCUMIN | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505121 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL505605 | — | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL500256 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL504265 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL526343 | — | IC50 | = | 7540.0 | nM | 5.12 |
| CHEMBL448227 | — | IC50 | = | 8150.0 | nM | 5.09 |
| CHEMBL509144 | — | IC50 | = | 17350.0 | nM | 4.76 |
| CHEMBL1213327 | COENZYME_A | IC50 | = | 45940.0 | nM | 4.34 |
| CHEMBL455368 | ANACARDIC ACID | IC50 | > | 1000000.0 | nM | - |
| CHEMBL140 | CURCUMIN | IC50 | > | 40000.0 | nM | - |