Assay Detail
Functional
CHEMBL1025619
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Agonist activity at human cloned alpha7 nAChR Gln117Phe mutant expressed in Xenopus laevis oocytes assessed as channel opening by voltage clamp electrophysiology
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 4.97 | 5.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162395 | — | — | 1 | 5.28 |
| CHEMBL193016 | — | — | 1 | 4.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162395 | — | EC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL193016 | — | EC50 | = | 22300.0 | nM | 4.65 |