Assay Detail
Binding
CHEMBL1025670
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Inhibition of JNK2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of highly selective and potent p38 inhibitors based on a phthalazine scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.35 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL494072 | — | — | 1 | 6.20 |
| CHEMBL493708 | — | — | 1 | 5.36 |
| CHEMBL494469 | — | — | 1 | 5.32 |
| CHEMBL492265 | — | — | 1 | 5.26 |
| CHEMBL493670 | — | — | 1 | 5.22 |
| CHEMBL493671 | — | — | 1 | 5.11 |
| CHEMBL494272 | — | — | 1 | 5.01 |
| CHEMBL495330 | — | — | 1 | - |
| CHEMBL494470 | — | — | 1 | - |
| CHEMBL494270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL494072 | — | IC50 | = | 629.0 | nM | 6.20 |
| CHEMBL493708 | — | IC50 | = | 4390.0 | nM | 5.36 |
| CHEMBL494469 | — | IC50 | = | 4831.0 | nM | 5.32 |
| CHEMBL492265 | — | IC50 | = | 5524.0 | nM | 5.26 |
| CHEMBL493670 | — | IC50 | = | 5954.0 | nM | 5.22 |
| CHEMBL493671 | — | IC50 | = | 7772.0 | nM | 5.11 |
| CHEMBL494272 | — | IC50 | = | 9685.0 | nM | 5.01 |
| CHEMBL495330 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL494470 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL494270 | — | IC50 | > | 10000.0 | nM | - |