Assay Detail
Binding
CHEMBL1025842
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electric eel AChE by Ellman's method
7
Total Activities
6
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Electrophorus electricus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Acetylcholinesterase inhibition by territrem B derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.93 | 6.77 |
| Activity | 1 | - | - |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452607 | 2,3-EPOXYTERRITREM B | — | 1 | 6.77 |
| CHEMBL24686 | TERRITREM B | — | 2 | 6.58 |
| CHEMBL479225 | 4BETA-IODOMETHYL-4BETA-DEMETHYL-TERRITREM B | — | 1 | 6.54 |
| CHEMBL471382 | 2,3-DIHYDROTERRITREM B | — | 1 | 5.66 |
| CHEMBL474870 | 1-DIHYDROTERRITREM B | — | 1 | 4.10 |
| CHEMBL516598 | 2,3,8,9-TETRAHYDRO-9,10-SECO-TERRITREM B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452607 | 2,3-EPOXYTERRITREM B | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL24686 | TERRITREM B | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL479225 | 4BETA-IODOMETHYL-4BETA-DEMETHYL-TERRITREM B | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL471382 | 2,3-DIHYDROTERRITREM B | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL474870 | 1-DIHYDROTERRITREM B | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL516598 | 2,3,8,9-TETRAHYDRO-9,10-SECO-TERRITREM B | Activity | - | — | - | |
| CHEMBL24686 | TERRITREM B | Inhibition | = | 50.0 | % | - |