Assay Detail
Functional
CHEMBL1025844
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Cytotoxicity against human A549 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Methyl ethers of podophyllotoxin-related cyclolignans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.11 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.92 |
| CHEMBL485470 | — | — | 1 | 7.60 |
| CHEMBL471390 | — | — | 1 | 7.22 |
| CHEMBL511650 | — | — | 1 | 7.22 |
| CHEMBL282256 | EPIPODOPHYLLOTOXIN | — | 1 | 7.22 |
| CHEMBL462933 | — | — | 1 | 6.92 |
| CHEMBL468247 | — | — | 1 | 6.89 |
| CHEMBL471389 | — | — | 1 | 6.22 |
| CHEMBL283120 | AXL-1717 | 2.0 | 1 | 5.22 |
| CHEMBL457589 | — | — | 1 | 5.01 |
| CHEMBL516675 | — | — | 1 | 5.01 |
| CHEMBL463348 | — | — | 1 | 5.01 |
| CHEMBL463550 | — | — | 1 | 4.94 |
| CHEMBL455532 | — | — | 1 | 4.94 |
| CHEMBL464350 | — | — | 1 | 4.33 |
| CHEMBL458034 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL485470 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL471390 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL511650 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL282256 | EPIPODOPHYLLOTOXIN | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL462933 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL468247 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL471389 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL283120 | AXL-1717 | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL457589 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL516675 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL463348 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL463550 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL455532 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL464350 | — | IC50 | = | 46300.0 | nM | 4.33 |
| CHEMBL458034 | — | IC50 | > | 38800.0 | nM | - |