Assay Detail
Binding
CHEMBL1026025
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Inhibition of exogenously transfected human Gli1-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporter gene assay
18
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C3H 10T1/2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 14 | - | - |
| IC50 | 4 | 5.02 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL561023 | — | — | 1 | 5.16 |
| CHEMBL551292 | — | — | 1 | 5.03 |
| CHEMBL560356 | — | — | 1 | 4.94 |
| CHEMBL562034 | — | — | 1 | 4.94 |
| CHEMBL559433 | — | — | 1 | - |
| CHEMBL562355 | — | — | 1 | - |
| CHEMBL563827 | — | — | 1 | - |
| CHEMBL152297 | — | — | 1 | - |
| CHEMBL539668 | — | — | 1 | - |
| CHEMBL538430 | — | — | 1 | - |
| CHEMBL571903 | — | — | 1 | - |
| CHEMBL541007 | — | — | 1 | - |
| CHEMBL562096 | — | — | 1 | - |
| CHEMBL558674 | — | — | 1 | - |
| CHEMBL562217 | — | — | 1 | - |
| CHEMBL552295 | — | — | 1 | - |
| CHEMBL75435 | DEXKETOPROFEN | 4.0 | 1 | - |
| CHEMBL254129 | CYCLOPAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL561023 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL551292 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL560356 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL562034 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL559433 | — | Inhibition | - | % | - | |
| CHEMBL562355 | — | Inhibition | - | % | - | |
| CHEMBL563827 | — | Inhibition | - | % | - | |
| CHEMBL152297 | — | Inhibition | - | % | - | |
| CHEMBL539668 | — | Inhibition | - | % | - | |
| CHEMBL538430 | — | Inhibition | - | % | - | |
| CHEMBL571903 | — | Inhibition | - | % | - | |
| CHEMBL541007 | — | Inhibition | - | % | - | |
| CHEMBL562096 | — | Inhibition | - | % | - | |
| CHEMBL558674 | — | Inhibition | - | % | - | |
| CHEMBL562217 | — | Inhibition | - | % | - | |
| CHEMBL552295 | — | Inhibition | - | % | - | |
| CHEMBL75435 | DEXKETOPROFEN | Inhibition | - | % | - | |
| CHEMBL254129 | CYCLOPAMINE | Inhibition | - | % | - |