Assay Detail
Binding
CHEMBL1026048
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Inhibition of exogenously transfected human Gli2 delta-N-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C3H 10T1/2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.57 | 4.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL551292 | — | — | 1 | 4.69 |
| CHEMBL561023 | — | — | 1 | 4.62 |
| CHEMBL560356 | — | — | 1 | 4.53 |
| CHEMBL562034 | — | — | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL551292 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL561023 | — | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL560356 | — | IC50 | = | 29400.0 | nM | 4.53 |
| CHEMBL562034 | — | IC50 | = | 35200.0 | nM | 4.45 |