Assay Detail
Binding
CHEMBL1026068
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Inhibition of Hsp90 in human AU565 cells assessed as Her2 degradation after 24 hrs by high content screening
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AU565 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 37 | 5.40 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 8.52 |
| CHEMBL560955 | — | — | 1 | 7.34 |
| CHEMBL562990 | — | — | 1 | 6.31 |
| CHEMBL559840 | — | — | 1 | 5.80 |
| CHEMBL552300 | — | — | 1 | 5.79 |
| CHEMBL563335 | — | — | 1 | 5.74 |
| CHEMBL553939 | — | — | 1 | 5.30 |
| CHEMBL554288 | — | — | 1 | 5.19 |
| CHEMBL563608 | — | — | 1 | 5.16 |
| CHEMBL563500 | — | — | 1 | 5.05 |
| CHEMBL560895 | SNX-2112 | -1.0 | 1 | 5.00 |
| CHEMBL561019 | — | — | 1 | 4.80 |
| CHEMBL564211 | — | — | 1 | 4.52 |
| CHEMBL561497 | — | — | 1 | 4.46 |
| CHEMBL558876 | — | — | 1 | 4.34 |
| CHEMBL538683 | — | — | 1 | 4.30 |
| CHEMBL549744 | — | — | 1 | 4.19 |
| CHEMBL551293 | — | — | 1 | - |
| CHEMBL564702 | — | — | 1 | - |
| CHEMBL552094 | — | — | 1 | - |
| CHEMBL556878 | — | — | 1 | - |
| CHEMBL561224 | — | — | 1 | - |
| CHEMBL549543 | — | — | 1 | - |
| CHEMBL562038 | — | — | 1 | - |
| CHEMBL562037 | — | — | 1 | - |
| CHEMBL551699 | — | — | 1 | - |
| CHEMBL561498 | — | — | 1 | - |
| CHEMBL550139 | — | — | 1 | - |
| CHEMBL561637 | — | — | 1 | - |
| CHEMBL564559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL560955 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL562990 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL559840 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL552300 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL563335 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL553939 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL554288 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL563608 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL563500 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL560895 | SNX-2112 | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL561019 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL564211 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL561497 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL558876 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL538683 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL549744 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL557478 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL559642 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL557479 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL560156 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL562929 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL556391 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL565035 | — | IC50 | = | 111000.0 | nM | - |
| CHEMBL564559 | — | IC50 | = | 229000.0 | nM | - |
| CHEMBL561637 | — | IC50 | = | 184000.0 | nM | - |
| CHEMBL550139 | — | IC50 | = | 418000.0 | nM | - |
| CHEMBL561498 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL551699 | — | IC50 | = | 226000.0 | nM | - |
| CHEMBL562037 | — | IC50 | = | 147000.0 | nM | - |
| CHEMBL562038 | — | IC50 | = | 115000.0 | nM | - |
| CHEMBL549543 | — | IC50 | = | 264000.0 | nM | - |
| CHEMBL561224 | — | IC50 | = | 248000.0 | nM | - |
| CHEMBL556878 | — | IC50 | > | 4000000.0 | nM | - |
| CHEMBL552094 | — | IC50 | > | 7000000.0 | nM | - |
| CHEMBL564702 | — | IC50 | = | 181000.0 | nM | - |
| CHEMBL551293 | — | IC50 | = | 203000.0 | nM | - |