Assay Detail
Binding
CHEMBL1026422
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Displacement of [3H]mesulergine from human cloned 5HT2C receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.43 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.98 |
| CHEMBL164471 | — | — | 1 | 7.46 |
| CHEMBL492689 | — | — | 1 | 6.61 |
| CHEMBL159929 | — | — | 1 | 6.47 |
| CHEMBL143027 | — | — | 1 | 6.47 |
| CHEMBL523680 | — | — | 1 | 6.43 |
| CHEMBL143022 | — | — | 1 | 5.81 |
| CHEMBL516809 | — | — | 1 | 5.48 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 5.14 |
| CHEMBL516944 | — | — | 1 | - |
| CHEMBL493069 | — | — | 1 | - |
| CHEMBL459930 | — | — | 1 | - |
| CHEMBL461627 | — | — | 1 | - |
| CHEMBL494702 | — | — | 1 | - |
| CHEMBL494701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 10.47 | nM | 7.98 |
| CHEMBL164471 | — | Ki | = | 34.67 | nM | 7.46 |
| CHEMBL492689 | — | Ki | = | 245.47 | nM | 6.61 |
| CHEMBL159929 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL143027 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL523680 | — | Ki | = | 371.54 | nM | 6.43 |
| CHEMBL143022 | — | Ki | = | 1548.82 | nM | 5.81 |
| CHEMBL516809 | — | Ki | = | 3311.31 | nM | 5.48 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 7244.36 | nM | 5.14 |
| CHEMBL516944 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL493069 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL459930 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL461627 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL494702 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL494701 | — | Ki | > | 10000.0 | nM | - |