Assay Detail
ADMET
CHEMBL1026425
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Cytotoxicity against BMEC by sulforhodamine B test
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Bos taurus |
| Cell Type | BMEC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.16 | 8.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.43 |
| CHEMBL462474 | — | — | 1 | 7.77 |
| CHEMBL509991 | — | — | 1 | 7.70 |
| CHEMBL502484 | — | — | 1 | 7.46 |
| CHEMBL511529 | — | — | 1 | 7.46 |
| CHEMBL47037 | Combretastatin A-2 | — | 1 | 7.32 |
| CHEMBL447389 | — | — | 1 | 6.96 |
| CHEMBL512560 | — | — | 1 | 6.91 |
| CHEMBL509714 | — | — | 1 | 6.60 |
| CHEMBL462056 | — | — | 1 | 6.10 |
| CHEMBL462055 | — | — | 1 | 6.06 |
| CHEMBL518818 | — | — | 1 | - |
| CHEMBL459937 | — | — | 1 | - |
| CHEMBL512217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL462474 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL509991 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL502484 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL511529 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL47037 | Combretastatin A-2 | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL447389 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL512560 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL509714 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL462056 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL462055 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL518818 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL459937 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL512217 | — | IC50 | > | 10000.0 | nM | - |