Assay Detail
Functional
CHEMBL1026426
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Cytotoxicity against human HT29 cells by sulforhodamine B test
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.76 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509991 | — | — | 1 | 7.68 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 6.93 |
| CHEMBL462474 | — | — | 1 | 6.58 |
| CHEMBL511529 | — | — | 1 | 6.38 |
| CHEMBL502484 | — | — | 1 | 6.23 |
| CHEMBL47037 | Combretastatin A-2 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509991 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL462474 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL511529 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL502484 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL47037 | Combretastatin A-2 | IC50 | > | 1000.0 | nM | - |