Assay Detail
Functional
CHEMBL1026427
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Cytotoxicity against human H460 cells by sulforhodamine B test
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.63 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.92 |
| CHEMBL502484 | — | — | 1 | 7.92 |
| CHEMBL462474 | — | — | 1 | 7.89 |
| CHEMBL509991 | — | — | 1 | 7.72 |
| CHEMBL511529 | — | — | 1 | 7.72 |
| CHEMBL47037 | Combretastatin A-2 | — | 1 | 7.40 |
| CHEMBL512560 | — | — | 1 | 6.96 |
| CHEMBL509714 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL502484 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL462474 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL509991 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL511529 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL47037 | Combretastatin A-2 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL512560 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL509714 | — | IC50 | = | 312.0 | nM | 6.51 |