Assay Detail
Binding
CHEMBL1026428
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Inhibition of tubulin polymerization
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.09 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL462474 | — | — | 1 | 8.54 |
| CHEMBL509991 | — | — | 1 | 8.44 |
| CHEMBL502484 | — | — | 1 | 8.41 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 8.31 |
| CHEMBL511529 | — | — | 1 | 8.29 |
| CHEMBL462056 | — | — | 1 | 8.15 |
| CHEMBL447389 | — | — | 1 | 7.91 |
| CHEMBL462055 | — | — | 1 | 7.85 |
| CHEMBL518818 | — | — | 1 | 7.78 |
| CHEMBL512217 | — | — | 1 | 7.67 |
| CHEMBL509714 | — | — | 1 | 7.61 |
| CHEMBL459937 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL462474 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL509991 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL502484 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL511529 | — | IC50 | = | 5.1 | nM | 8.29 |
| CHEMBL462056 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL447389 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL462055 | — | IC50 | = | 14.2 | nM | 7.85 |
| CHEMBL518818 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL512217 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL509714 | — | IC50 | = | 24.3 | nM | 7.61 |
| CHEMBL459937 | — | IC50 | > | 100.0 | nM | - |