Assay Detail
Binding
CHEMBL1026429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]colchicine from tubulin by scintillation proximity assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel A-ring and B-ring modified combretastatin A-4 (CA-4) analogues endowed with interesting cytotoxic activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 9.10 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL511529 | — | — | 1 | 10.70 |
| CHEMBL462474 | — | — | 1 | 10.70 |
| CHEMBL502484 | — | — | 1 | 10.30 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 10.00 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.77 |
| CHEMBL447389 | — | — | 1 | 8.42 |
| CHEMBL462056 | — | — | 1 | 8.40 |
| CHEMBL462055 | — | — | 1 | 8.31 |
| CHEMBL459937 | — | — | 1 | 8.21 |
| CHEMBL509991 | — | — | 1 | 8.21 |
| CHEMBL518818 | — | — | 1 | 8.11 |
| CHEMBL509714 | — | — | 1 | - |
| CHEMBL512217 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL511529 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL462474 | — | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL502484 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL107 | COLCHICINE | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL447389 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL462056 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL462055 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL459937 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL509991 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL518818 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL509714 | — | IC50 | - | — | - | |
| CHEMBL512217 | — | IC50 | - | — | - |