Assay Detail
Functional
CHEMBL1026574
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Agonist activity at LXRbeta by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.44 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446208 | — | — | 1 | 8.40 |
| CHEMBL505808 | — | — | 1 | 8.15 |
| CHEMBL505520 | — | — | 1 | 7.92 |
| CHEMBL471641 | — | — | 1 | 7.82 |
| CHEMBL457452 | — | — | 1 | 7.82 |
| CHEMBL513949 | — | — | 1 | 7.64 |
| CHEMBL59030 | — | — | 1 | 7.60 |
| CHEMBL518000 | — | — | 1 | 7.58 |
| CHEMBL480493 | — | — | 1 | 7.22 |
| CHEMBL499550 | — | — | 1 | 6.54 |
| CHEMBL451889 | — | — | 1 | 6.29 |
| CHEMBL450200 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446208 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL505808 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL505520 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL471641 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL457452 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL513949 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL59030 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL518000 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL480493 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL499550 | — | EC50 | = | 288.0 | nM | 6.54 |
| CHEMBL451889 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL450200 | — | EC50 | = | 560.0 | nM | 6.25 |