Assay Detail
Binding
CHEMBL1026664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNA polymerase beta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Mechanistic evaluation of new plant-derived compounds that inhibit HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.01 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL454727 | — | — | 1 | 5.66 |
| CHEMBL490329 | PROTOLICHESTERINIC ACID | — | 1 | 5.13 |
| CHEMBL504840 | SWERTIFRANCHESIDE | — | 1 | 4.24 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL454727 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL490329 | PROTOLICHESTERINIC ACID | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL504840 | SWERTIFRANCHESIDE | IC50 | = | 57700.0 | nM | 4.24 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 20000.0 | nM | - |