Assay Detail
Functional
CHEMBL1026744
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Cytotoxicity against human SF268 cells after 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SF-268 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Aspochalasins I, J, and K: three new cytotoxic cytochalasans of Aspergillus flavipes from the rhizosphere of Ericameria laricifolia of the Sonoran Desert.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.24 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.66 |
| CHEMBL519431 | ASPOCHALASIN C | — | 1 | 5.41 |
| CHEMBL479328 | ASPOCHALASIN D | — | 1 | 5.30 |
| CHEMBL472639 | — | — | 1 | 5.02 |
| CHEMBL480287 | ASPOCHALASIN J | — | 1 | 4.87 |
| CHEMBL478599 | ASPOCHALASIN I | — | 1 | 4.70 |
| CHEMBL480485 | ASPOCHALASIN K | — | 1 | 4.70 |
| CHEMBL516341 | ASPOCHALASIN E | — | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 21.7 | nM | 7.66 |
| CHEMBL519431 | ASPOCHALASIN C | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL479328 | ASPOCHALASIN D | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL472639 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL480287 | ASPOCHALASIN J | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL478599 | ASPOCHALASIN I | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL480485 | ASPOCHALASIN K | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL516341 | ASPOCHALASIN E | IC50 | = | 52600.0 | nM | 4.28 |