Assay Detail
Binding
CHEMBL1027240
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Displacement of [3H]spiperone from human cloned dopamine D2 receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, binding affinity, and molecular docking analysis of new benzofuranone derivatives as potential antipsychotics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.35 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.22 |
| CHEMBL516809 | — | — | 1 | 7.92 |
| CHEMBL523680 | — | — | 1 | 7.80 |
| CHEMBL143027 | — | — | 1 | 7.79 |
| CHEMBL492689 | — | — | 1 | 7.38 |
| CHEMBL164471 | — | — | 1 | 7.34 |
| CHEMBL461627 | — | — | 1 | 7.07 |
| CHEMBL143022 | — | — | 1 | 6.82 |
| CHEMBL459930 | — | — | 1 | 6.67 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.65 |
| CHEMBL159929 | — | — | 1 | 6.14 |
| CHEMBL516944 | — | — | 1 | - |
| CHEMBL493069 | — | — | 1 | - |
| CHEMBL494702 | — | — | 1 | - |
| CHEMBL494701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.6026 | nM | 9.22 |
| CHEMBL516809 | — | Ki | = | 12.02 | nM | 7.92 |
| CHEMBL523680 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL143027 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL492689 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL164471 | — | Ki | = | 45.71 | nM | 7.34 |
| CHEMBL461627 | — | Ki | = | 85.11 | nM | 7.07 |
| CHEMBL143022 | — | Ki | = | 151.36 | nM | 6.82 |
| CHEMBL459930 | — | Ki | = | 213.8 | nM | 6.67 |
| CHEMBL42 | CLOZAPINE | Ki | = | 223.87 | nM | 6.65 |
| CHEMBL159929 | — | Ki | = | 724.44 | nM | 6.14 |
| CHEMBL516944 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL493069 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL494702 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL494701 | — | Ki | > | 10000.0 | nM | - |