Assay Detail
Binding
CHEMBL1027370
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Inhibition of human G-quadruplex [TTAGGG]4 DNA templet extension assessed as increase in ligand-induced polymerase stop products by Taq DNA polymerase stop assay
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.42 | 7.15 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443702 | — | — | 1 | 7.15 |
| CHEMBL506865 | — | — | 2 | 6.70 |
| CHEMBL448813 | — | — | 1 | 6.07 |
| CHEMBL336434 | — | — | 2 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443702 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL506865 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL448813 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL336434 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL506865 | — | Activity | - | — | - | |
| CHEMBL336434 | — | Activity | - | — | - |