Assay Detail
Binding
CHEMBL1027379
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Inhibition of non G-quadruplex [TTAGAG]4 DNA templet extension assessed as ligand-induced polymerase stop products by Taq DNA polymerase stop assay
6
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
BRACO19 analog dimers with improved inhibition of telomerase and hPot 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.48 | 6.44 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443702 | — | — | 1 | 6.44 |
| CHEMBL506865 | — | — | 2 | 5.41 |
| CHEMBL448813 | — | — | 1 | 5.35 |
| CHEMBL336434 | — | — | 2 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443702 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL506865 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL448813 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL336434 | — | EC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL336434 | — | Activity | - | — | - | |
| CHEMBL506865 | — | Activity | - | — | - |